OWL Genomics

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Selección de artículos científicos

Todos los artículos científicos de los que son autores los investigadores de OWL Genomics se pueden consultar a través de la página Web del servicio PubMed del National Center for Biothecnology Information: www.ncbi.nlm.nih.gov/pubmed

 

Liquid Chromatography-Mass Spectrometry (LC/MS)-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of non-alcoholic fatty liver disease.

Barr J, Alonso C, Vázquez-Chantada M, Perez-Cormenzana M, Mayo R, Galán A, Caballería J, Martín-Duce A, Tran A, Wagner C, Luka Z, Lu SC, Castro A, Le Marchand-Brustel Y, Martínez-Chantar ML, Veyrie N, Clément K, Tordjman J, Gual P, Mato JM.

Publication Date (Web): July 15, 2010 (Article)
DOI: 10.1021/pr1002593

 

 

Metabolomicmodellingof drug toxicity. An activity of the MeliusProject.

M. Vazquez-Chantada, J Barr, C. Alonso, A. Castro, N. Fabre, J.A. Vericat.

"Toxicology Letters" Volume 196S, 17 July 2010; S1-S352. ISSN 0378-4274.

 

 

Ultra-Performance Liquid ChromatographyTM High Definition Mass Spectrometry (UPLCTM-HDMSTM) as a useful tool in predictive drug toxicology. An activity of Melius Proyect.

J. Barr, M. Vazquez-Chantada, C. Alonso, A. Castro, N. Fabre, J.A. Vericat

"Toxicology Letters" Volume 196S, 17 July 2010; S1-S352. ISSN 0378-4274.

 

 

Sirtuin 1 regulation of developmental genes during differentiation of stem cells.

Calvanese V, Lara E, Suárez-Álvarez B, Abu Dawud R, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, Andrews PW, López-Larrea C, Esteller M, Fraga MF.

Proc Natl Acad Sci U S A. 2010 Jul 14. [Epub ahead of print] PMID: 20631301

 

 

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide.

Varela-Rey M, Martínez-López N, Fernández-Ramos D, Embade N, Calvisi DF, Woodhoo A, Rodríguez J, Fraga MF, Julve J, Rodríguez-Millán E, Frades I, Torres L, Luka Z, Wagner C, Esteller M, Lu SC, Martínez-Chantar ML, Mato JM.

Hepatology. 2010 Jul;52(1):105-14. PMID: 20578266

 

 

S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes.

Tomasi ML, Ramani K, Lopitz-Otsoa F, Rodríguez MS, Li TW, Ko K, Yang H, Bardag-Gorce F, Iglesias-Ara A, Feo F, Pascale MR, Mato JM, Lu SC.

Hepatology. 2010 Jun;51(6):2152-61. PMID: 20196119

 

 

HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis.

Vázquez-Chantada M, Fernández-Ramos D, Embade N, Martínez-Lopez N, Varela-Rey M, Woodhoo A, Luka Z, Wagner C, Anglim PP, Finnell RH, Caballería J, Laird-Offringa IA, Gorospe M, Lu SC, Mato JM, Martínez-Chantar ML.

Gastroenterology. 2010 May;138(5):1943-53. Epub 2010 Jan 25. PMID: 20102719

 

 

The role of stem cells/progenitor cells in liver carcinogenesis in glycine N-methyltransferase deficient mice.

Martinez-Chantar ML, Lu SC, Mato JM, Luka Z, Wagner C, French BA, French SW.

Exp Mol Pathol. 2010 Apr;88(2):234-7. Epub 2010 Jan 19. PMID: 20080087

 

 

Activation of LKB1-Akt pathway independent of PI3 Kinase plays a critical role in the proliferation of hepatocellular carcinoma from NASH.

Martínez-López N, Varela-Rey M, Fernández-Ramos D, Woodhoo A, Vázquez-Chantada M, Embade N, Espinosa-Hevia L, Bustamante FJ, Parada LA, Rodriguez MS, Lu SC, Mato JM, Martinez-Chantar ML.

Hepatology 2010. In press

 

 

Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.

Conde-Vancells J, Rodriguez-Suarez E, Gonzalez E, Berisa A, Gil D, Embade N, Valle M, Luka Z, Elortza F, Wagner C, Lu SC, Mato JM, Falcon-Perez JM.

Proteomics Clin Appl. 2010 Feb 3;4(4):416-425. PMID: 20535238

 

 

S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model.

Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E.

Hepatology. 2009 Aug;50(2):462-71. PMID: 19444874

 

 

Impaired liver regeneration in mice lacking glycine N-methyltransferase.

Varela-Rey M, Fernández-Ramos D, Martínez-López N, Embade N, Gómez-Santos L, Beraza N, Vázquez-Chantada M, Rodríguez J, Luka Z, Wagner C, Lu SC, Martínez-Chantar ML, Mato JM.

Hepatology. 2009 Aug;50(2):443-52. PMID: 19582817

 

 

Hepatocellular carcinoma in GNMT-/- mice.

Wagner C, Luka Z, Mato JM.

Toxicol Appl Pharmacol. 2009 Jun 1;237(2):246; author reply 247. Epub 2009 Apr 1. No abstract available. PMID: 19345238

 

 

Non-alcoholic steatohepatitis and animal models: understanding the human disease.

Varela-Rey M, Embade N, Ariz U, Lu SC, Mato JM, Martínez-Chantar ML.

Int J Biochem Cell Biol. 2009 May;41(5):969-76. Epub 2008 Nov 5.

 

 

S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.

Tomasi ML, Iglesias-Ara A, Yang H, Ramani K, Feo F, Pascale MR, Martínez-Chantar ML, Mato JM, Lu SC.

Gastroenterology. 2009 Mar;136(3):1025-36. Epub 2008 Sep 25.

 

 

Evidence of LKB1/AMP-activated protein kinase / endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxyde in hepatocyte proliferation.

Vázquez-Chantada M, Ariz U, Varela-Rey M, Embade M, Martínez-López N, Fernández-Ramos D, Gómez-Santos L, Lamas S, Lu SC, Martínez-Chantar ML, Mato JM.

Hepatology. 2009 Feb;49(2):608-17.

 

 

Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes.

Conde-Vancells J, Rodríguez-Suárez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM.

Journal of Proteome Research. 2008 Dec;7(12):5157-66.

 

 

S-adenosylmethionine and proliferation: new pathways, new targets.

Martínez-López N, Varela-Rey M, Ariz U, Embade N, Vázquez-Chantada M, Fernández-Ramos D, Gómez-Santos L, Lu SC, Mato JM, Martínez-Chantar ML.

Biochem Soc Trans. 2008 Oct;36(Pt 5):848-52.

 

 

Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice.

Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC.

Hepatology. 2008 Apr;47(4):1288-97.

 

 

Loss of the glycine n-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice.

Martínez-Chantar ML, Vázquez-Chantada M, Ariz U, Martínez N, Varela M, Luka Z, Capdevilla A, Rodríguez J, Aransay AM, Matthiesen R, Yang H, Calvisi DF, Esteller M, Fraga M, Lu SC, Wagner C, Mato JM.

Hepatology. 2008 Apr;47(4):1191-9.

 

 

Methionine metabolism and liver disease.

Mato JM, Martínez-Chantar ML, Lu SC.

Annu Rev Nutr. 2008;28:273-93.

 

 

S-adenosylmethionine in cell growth, apoptosis and liver cancer.

Lu, SC, Mato JM.

J Gastroenterol Hepatol. 2008 Mar;23 Suppl 1:S73-7.

 

 

Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma.

Yuan JM, Lu SC, Van Den Berg D, Govindarajan S, Zhang ZQ, Mato JM, Yu MC.

Hepatology. 2007 Sep;46(3):749-58.

 

 

Role of s-adenosyl-l-methionine in liver health and injury.

Mato JM, Lu SC.

Hepatology. 2007 May;45(5):1306-12.

 

 

Identification of a gene-pathway associated with non-alcoholic steatohepatitis.

Rubio A, Guruceaga E, Vázquez-Chantada M, Sandoval J, Martínez-Cruz LA, Segura V, Sevilla JL, Podhorski A, Corrales FJ, Torres L, Rodríguez M, Aillet F, Ariz U, Arrieta FM, Caballería J, Martín-Duce A, Lu SC, Martínez-Chantar ML, Mato JM.

J Hepatol. 2007 Apr;46(4):708-18. Epub 2006 Nov 30.

 

 

Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells.

Rodríguez JL, Boukaba A, Sandoval J, Georgieva EI, Latasa MU, García-Trevijano ER, Serviddio G, Nakamura T, Avila MA, Sastre J, Torres L, Mato JM, López-Rodas G.

Int J Biochem Cell Biol. 2007;39(4):842-50. Epub 2007 Jan 20.

 

 

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Última actualización: 29/07/2010

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